Scientific Publications
The InPharma research results have been submitted to and published in scientific, peer-reviewed journals.
The European Journal of Pharmaceutical Sciences granted our project a special issue InPharma – Scientific contributions towards future oral drug product development. The Special Issue stayed open to collect scientific papers throughout the project.
2025
- Lange, J. J., Enzner, L., Kuentz, M., O’Dwyer, P. J., Saal, W., Griffin, B. T., & Wyttenbach, N. (2025). Exploration of solubilisation effects facilitated by the combination of Soluplus® with ionic surfactants. European Journal of Pharmaceutical Sciences, 205, 106957. doi.org/10.1016/j.ejps.2024.106957
- Panbachi, S., Beranek, J., & Kuentz, M. (2025). Abiraterone acetate fixed-dosed combinations with ibuprofen-based therapeutic eutectic and deep eutectic solvents. International Journal of Pharmaceutics, 125279. doi.org/10.1016/j.ijpharm.2025.125279
2024
- Zöller, L., Avdeef, A., Karlsson, E., Borde, A., Carlert, S., Saal, C., & Dressman, J. (2024). A comparison of USP 2 and µDISS Profiler™ apparatus for studying dissolution phenomena of ibuprofen and its salts. European Journal of Pharmaceutical Sciences, 193, 106684. doi.org/10.1016/j.ejps.2023.106684
- Lange, J. J., Anelli, A., Alsenz, J., Kuentz, M., O’Dwyer, P. J., Saal, W., … & Griffin, B. T. (2024). Comparative Analysis of Chemical Descriptors by Machine Learning Reveals Atomistic Insights into Solute–Lipid Interactions. Molecular Pharmaceutics. doi.org/10.1021/acs.molpharmaceut.4c00080
- Beran, K., Hermans, E., Holm, R., Sepassi, K., & Dressman, J. (2024). A Stratified Analysis of Supersaturation and Precipitation Effects Based on the Refined Developability Classification System (rDCS). Journal of Pharmaceutical Sciences. doi.org/10.1016/j.xphs.2024.06.014
- Holzem, F. L., Parrott, N., Schaffland, J. P., Brandl, M., Bauer-Brandl, A., & Stillhart, C. (2024). Oral absorption from surfactant-based drug formulations: the impact of molecularly dissolved drug on bioavailability. Journal of Pharmaceutical Sciences, 113(10), 3054-3064. doi.org/10.1016/j.xphs.2024.07.017
- Panbachi, S., Beranek, J., & Kuentz, M. (2024). Hydrophobic deep eutectic solvent (HDES) as oil phase in lipid-based drug formulations. International Journal of Pharmaceutics, 661, 124418. doi.org/10.1016/j.ijpharm.2024.124418
- Ejskjær, L., Holm, R., Kuentz, M., Box, K. J., Griffin, B. T., & O’Dwyer, P. J. (2024). Predictions of biorelevant solubility change during dispersion and digestion of lipid-based formulations. European Journal of Pharmaceutical Sciences, 106833. doi.org/10.1016/j.ejps.2024.106833
- Beran, K., Hermans, E., Holm, R., Sepassi, K., & Dressman, J. (2024). Using the refined Developability Classification System (rDCS) to guide the design of oral formulations. Journal of Pharmaceutical Sciences, 113(12), 3497-3517. doi.org/10.1016/j.xphs.2024.09.022
- Beran, K., Abrahamsson, A., Charoo, N., Cristofoletti, R., Holm, R., Kambayashif, A., Langguth, P., Mehta, M., Parr, A., Polli, J. E., Shah, V. P., Dressman, J. (2024). Biowaiver monographs for immediate-release solid oral dosage forms: Lemborexant. Journal of Pharmaceutical Sciences, 0 (0), 1-16. doi.org/10.1016/j.xphs.2024.10.030
- Beran, K., Abrahamsson, B., Charoo, N., Cristofoletti, R., Holm, R., Kambayashi, A., … & Dressman, J. (2024). Biowaiver monographs for immediate-release solid oral dosage forms: Voriconazole. Journal of pharmaceutical sciences. doi.org/10.1016/j.xphs.2024.10.055
- Holzem, F. L., Mikkelsen, R. L., Schaffland, J. P., Stillhart, C., Brandl, M., & Bauer-Brandl, A. (2024). A high-throughput micro-scale workflow to quantify molecularly dissolved drug concentrations under solubilizing conditions. Journal of Pharmaceutical Sciences. doi.org/10.1016/j.xphs.2024.12.027
- Beran, K., Dressman, J., Hermans, E., Holm, R., & Sepassi, K. (2024). Advantages of the refined Developability Classification System (rDCS) in early discovery. Journal of Pharmaceutical Sciences. doi.org/10.1016/j.xphs.2024.12.021
- Dietrich S., Dimoula M., Argyropoulos T., Ceuleman J., Goumas K., Vertzoni M. & Reppas C. (2024). On the processes limiting oral drug absorption when amorphous solid dispersions are administered after a high-calorie, high-fat meal: Sporanox® pellets. European Journal of Pharmaceutical Sciences, 199, 106798. doi.org/10.1016/j.ejps.2024.106798
- Pätzmann N., O’Dwyer P. J., Beránek J., Kuentz M. & Griffin B. T. (2024). Predictive computational models for assessing the impact of co-milling on drug dissolution. European Journal of Pharmaceutical Sciences, 198, 106780. doi.org/10.1016/j.ejps.2024.106780
- Zeneli E., Lange J. J., Holm R. & Kuentz M. (2024). A study of hydrophobic domain formation of polymeric drug precipitation inhibitors in aqueous solution. European Journal of Pharmaceutical Sciences, 198, 106791. doi.org/10.1016/j.ejps.2024.106791
- Guidetti M., Hilfiker R., Kuentz M., Bauer-Brandl A. & Blatter F. (2024). Water-mediated phase transformations of posaconazole: An intricate jungle of crystal forms. European Journal of Pharmaceutical Sciences, 195, 106722. doi.org/10.1016/j.ejps.2024.106722
- Holzem F. L., Schaffland J. P., Brandl M., Bauer-Brandl A.& Stillhart C. (2024). Using molecularly dissolved drug concentrations in PBBMs improves the prediction of oral absorption from supersaturating formulations. European Journal of Pharmaceutical Sciences, 194, 106703. doi.org/10.1016/j.ejps.2024.106703
- Dietrich S., Ceulemans J., Hermans E., Argyropoulos T., Goumas K., Vertzoni M. & Reppas C. (2024). Understanding the Conditions Under Which Drugs are Transferred from the Stomach Through the Upper Small Intestine After a High-Calorie, High-Fat Meal. Journal of Pharmaceutical Sciences, 113. doi.org/10.1016/j.xphs.2024.01.001
- Zöller L., Avdeef A., Karlsson E., Borde A., Carlert S., Saal C. & Dressman J. (2024). A comparison of dissolution and precipitation of ibuprofen and its salts in the USP II and the µDISS Profiler™ apparatus. European Journal of Pharmaceutical Sciences, 193, 106684. doi.org/10.1016/j.ejps.2023.106684
- Ejskjaer L., O’Dwyer P. J., Ryan C. D., Holm R., Kuentz M., Box K. J. & Griffin B. T. (2024). Developing an in vitro lipolysis model for real-time analysis of drug concentrations during digestion of lipid-based formulations. European Journal of Pharmaceutical Sciences, 194, 106681. doi.org/10.1016/j.ejps.2023.106681
- Paulus F., Bauer-Brandl A., Stappaerts J. & Holm R. (2024). Digestion is a critical element for absorption of cinnarizine from supersaturated lipid-based type I formulations. European Journal of Pharmaceutical Sciences, 192, 106634. doi.org/10.1016/j.ejps.2023.106634
2023
- Murray J. D., Lange J. J., Bennett-Lenane H., Holm R., Kuentz M., O’Dwyer P. J. & Griffin B. T. (2023). Advancing algorithmic drug product development: Recommendations for machine learning approaches in drug formulation. European Journal of Pharmaceutical Sciences, 191, 106562. doi.org/10.1016/j.ejps.2023.106562
- Reppas C., Kuentz M., Bauer-Brandl A., Carlet S., Dallmann A., Dietrich S., Dressman J., Ejskjaer L., Frechen S., Guidetti M., Holm R., Holzem F. L., Karlsson E., Kostewicz E., Panbachi S., Paulus F., Senniksen M. B., Stillhart C. Turner D. B., Vertzoni M. & O’Dwyer P. J. (2023). Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary. European Journal of Pharmaceutical Sciences, 188, 106505. doi.org/10.1016/j.ejps.2023.106505
- Beran, K., Hermans, E., Holm, R., Sepassi, K. & Dressman J. (2023). Projection of Target Drug Particle Size in Oral Formulations Using the Refined Developability Classification System (rDCS). Pharmaceutics, 15. doi.org/10.3390/pharmaceutics15071909
- Holzem F. L., Jensen I. H., Schaffland J. P., Stillhart C., Brandl M. & Bauer-Brandl A. (2023). Combining in vitro dissolution/permeation with microdialysis sampling: Capabilities and limitations for biopharmaceutical assessments of supersaturating drug formulations. European Journal of Pharmaceutical Sciences, 188, 106533. doi.org/10.1016/j.ejps.2023.106533
- Panbachi S., Beranek J. & Kuentz M. (2023). Polymer-embedded deep eutectic solvents (PEDES) as a novel bio-enabling formulation approach. European Journal of Pharmaceutical Sciences, 186, 106463. doi.org/10.1016/j.ejps.2023.106463
2022
- Guidetti M., Hilfiker R., Kuentz M., Bauer-Brandl A. & Blatter F. (2022). Exploring the Cocrystal Landscape of Posaconazole by Combining High-Throughput Screening Experimentation with Computational Chemistry. Crystal Growth & Design, 23. doi.org/10.1021/acs.cgd.2c01072
- Holzem F. L., Weck A., Schaffland J. P., Stillhart C., Klein S., Bauer-Brandl A. & Brandl M. (2022). Biopredictive capability assessment of two dissolution/permeation assays, µFLUX™ and PermeaLoop™, using supersaturating formulations of Posaconazole. European Journal of Pharmaceutical Sciences, 176, 106260. doi.org/10.1016/j.ejps.2022.106260
- Holzem F. L., Schaffland J. P., Brandl M., Bauer-Brandl A. & Stillhart C. (2022). Microdialysis and nanofiltration allow to distinguish molecularly dissolved from colloid-associated drug concentrations during biomimetic dissolution testing of supersaturating formulations. European Journal of Pharmaceutical Sciences, 174, 106166. doi.org/10.1016/j.ejps.2022.106166
Questions about our dissemination activities and results? Contact us:
Prof. Brendan Griffin, University College Cork
InPharma Coordinator
[email protected]
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