This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 955756.

Scientific Publications​

The first research results have been submitted to and published in scientific, peer-reviewed journals. 

  • Dietrich S., Dimoula M., Argyropoulos T., Ceuleman J., Goumas K., Vertzoni M. & Reppas C. (2024). On the processes limiting oral drug absorption when amorphous solid dispersions are administered after a high-calorie, high-fat meal: Sporanox® pellets. European Journal of Pharmaceutical Sciences, 199, 106798. doi.org/10.1016/j.ejps.2024.106798
  • Pätzmann N., O’Dwyer P. J., Beránek J., Kuentz M. & Griffin B. T. (2024). Predictive computational models for assessing the impact of co-milling on drug dissolution. European Journal of Pharmaceutical Sciences, 198, 106780. doi.org/10.1016/j.ejps.2024.106780 
  • Zeneli E., Lange J. J., Holm R. & Kuentz M. (2024). A study of hydrophobic domain formation of polymeric drug precipitation inhibitors in aqueous solution. European Journal of Pharmaceutical Sciences, 198, 106791. doi.org/10.1016/j.ejps.2024.106791
  • Guidetti M., Hilfiker R., Kuentz M., Bauer-Brandl A. & Blatter F. (2024). Water-mediated phase transformations of posaconazole: An intricate jungle of crystal forms. European Journal of Pharmaceutical Sciences, 195, 106722. doi.org/10.1016/j.ejps.2024.106722
  • Holzem F. L., Schaffland J. P., Brandl M., Bauer-Brandl A.&  Stillhart C. (2024). Using molecularly dissolved drug concentrations in PBBMs improves the prediction of oral absorption from supersaturating formulations. European Journal of Pharmaceutical Sciences, 194, 106703. doi.org/10.1016/j.ejps.2024.106703
  • Dietrich S., Ceulemans J., Hermans E., Argyropoulos T., Goumas K., Vertzoni M. & Reppas C. (2024). Understanding the Conditions Under Which Drugs are Transferred from the Stomach Through the Upper Small Intestine After a High-Calorie, High-Fat Meal. Journal of Pharmaceutical Sciences, 113. doi.org/10.1016/j.xphs.2024.01.001
  • Zöller L., Avdeef A., Karlsson E., Borde A., Carlert S., Saal C. & Dressman J. (2024). A comparison of dissolution and precipitation of ibuprofen and its salts in the USP II and the µDISS Profiler™ apparatus. European Journal of Pharmaceutical Sciences, 193, 106684. doi.org/10.1016/j.ejps.2023.106684
  • Ejskjaer L., O’Dwyer P. J., Ryan C. D., Holm R., Kuentz M., Box K. J. & Griffin B. T. (2024). Developing an in vitro lipolysis model for real-time analysis of drug concentrations during digestion of lipid-based formulations. European Journal of Pharmaceutical Sciences, 194, 106681. doi.org/10.1016/j.ejps.2023.106681
  • Murray J. D., Lange J. J., Bennett-Lenane H., Holm R., Kuentz M., O’Dwyer P. J. & Griffin B. T. (2023). Advancing algorithmic drug product development: Recommendations for machine learning approaches in drug formulation. European Journal of Pharmaceutical Sciences, 191, 106562. doi.org/10.1016/j.ejps.2023.106562
  • Reppas C., Kuentz M., Bauer-Brandl A., Carlet S., Dallmann A., Dietrich S., Dressman J., Ejskjaer L., Frechen S., Guidetti M., Holm R., Holzem F. L., Karlsson E., Kostewicz E., Panbachi S., Paulus F., Senniksen M. B., Stillhart C. Turner D. B., Vertzoni M. & O’Dwyer P. J. (2023). Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary. European Journal of Pharmaceutical Sciences, 188, 106505. doi.org/10.1016/j.ejps.2023.106505
  • Beran, K., Hermans, E., Holm, R., Sepassi, K. & Dressman J. (2023). Projection of Target Drug Particle Size in Oral Formulations Using the Refined Developability Classification System (rDCS). Pharmaceutics, 15. doi.org/10.3390/pharmaceutics15071909
  • Holzem F. L., Jensen I. H., Schaffland J. P., Stillhart C., Brandl M. & Bauer-Brandl A. (2023). Combining in vitro dissolution/permeation with microdialysis sampling: Capabilities and limitations for biopharmaceutical assessments of supersaturating drug formulations. European Journal of Pharmaceutical Sciences, 188, 106533. doi.org/10.1016/j.ejps.2023.106533
  • Panbachi S., Beranek J. & Kuentz M. (2023). Polymer-embedded deep eutectic solvents (PEDES) as a novel bio-enabling formulation approach. European Journal of Pharmaceutical Sciences, 186, 106463. doi.org/10.1016/j.ejps.2023.106463
  • Guidetti M., Hilfiker R., Kuentz M., Bauer-Brandl A. & Blatter F. (2022). Exploring the Cocrystal Landscape of Posaconazole by Combining High-Throughput Screening Experimentation with Computational Chemistry. Crystal Growth & Design, 23. doi.org/10.1021/acs.cgd.2c01072
  • Holzem F. L., Weck A., Schaffland J. P., Stillhart C., Klein S., Bauer-Brandl A. & Brandl M. (2022). Biopredictive capability assessment of two dissolution/permeation assays, µFLUX™ and PermeaLoop™, using supersaturating formulations of Posaconazole. European Journal of Pharmaceutical Sciences, 176, 106260. doi.org/10.1016/j.ejps.2022.106260
  • Holzem F. L., Schaffland J. P., Brandl M., Bauer-Brandl A. & Stillhart C. (2022). Microdialysis and nanofiltration allow to distinguish molecularly dissolved from colloid-associated drug concentrations during biomimetic dissolution testing of supersaturating formulations. European Journal of Pharmaceutical Sciences, 174, 106166. doi.org/10.1016/j.ejps.2022.106166
 
 The European Journal of Pharmaceutical Sciences has granted the our project a special issue InPharma – Scientific contributions towards future oral drug product development. The Special Issue shall stay open to collect scientific papers throughout the project period. 

Questions about our dissemination activities and results? Contact us:

Prof. Brendan Griffin, University College Cork
InPharma Coordinator
[email protected]

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